Peer Reviewed Papers








Spycher BD, Cochrane C, Granell R, Sterne JAC, Silverman M, Pedersen E, Gaillard EA, Henderson J, Kuehni CE.

Temporal stability of multitrigger and episodic viral wheeze in early childhood

Eur Respir J. 2017 Nov 2;50(5). pii: 1700014. doi: 10.1183/13993003.00014-2017. Print 2017 Nov.


Wang J, Ramette A, Jurca M, Goutaki M, Beardsmore CS, Kuehni CE.

Association between breastfeeding and eczema during childhood and adolescence: A cohort study.

PLoS One. 2017 Sep 25;12(9):e0185066. doi: 10.1371/journal.pone.0185066. eCollection 2017.


Jurca M, Pescatore AM, Goutaki M, Spycher BD, Beardsmore CS, Kuehni CE.

Age-related changes in childhood wheezing characteristics: A whole population study

Pediatr Pulmonol. 2017 Oct;52(10):1250-1259. doi: 10.1002/ppul.23783. Epub 2017 Aug 16.


Wang J, Ramette A, Jurca M, Goutaki M, Beardsmore CS, Kuehni CE.

Breastfeeding and respiratory tract infections during the first 2 years of life

ERJ Open Res. 2017 Jun 2;3(2). pii: 00143-2016. doi: 10.1183/23120541.00143-2016. eCollection 2017 Apr.


Jurca M, Ramette A, Dogaru CM, Goutaki M, Spycher BD, Latzin P, Gaillard EA, Kuehni CE.

Prevalence of cough throughout childhood: A cohort study.

PLoS One. 2017 May 24;12(5):e0177485. doi: 10.1371/journal.pone.0177485. eCollection 2017.





Lum S, Bountziouka V, Quanjer P, Sonnappa S, Wade A, Beardsmore C, Chhabra SK, Chudasama RK, Cook DG, Harding S, Kuehni CE, Prasad KV, Whincup PH, Lee S, Stocks J.

Challenges in Collating Spirometry Reference Data for South-Asian Children: An Observational Study.

PLoS One. 2016 Apr 27;11(4):e0154336. doi: 10.1371/journal.pone.0154336. eCollection 2016.


Vardavas CI, Hohmann C, Patelarou E, Martinez D, Henderson AJ, Granell R, Sunyer J, Torrent M, Fantini MP, Gori D, Annesi-Maesano I, Slama R, Duijts L, de Jongste JC, Aurrekoetxea JJ, Basterrechea M, Morales E, Ballester F, Murcia M, Thijs C, Mommers M, Kuehni CE, Gaillard EA, Tischer C, Heinrich J, Pizzi C, Zugna D, Gehring U, Wijga A, Chatzi L, Vassilaki M, Bergström A, Eller E, Lau S, Keil T, Nieuwenhuijsen M, Kogevinas M.

The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children

Eur Respir J. 2016 Jul;48(1):115-24. doi: 10.1183/13993003.01016-2015. Epub 2016 Mar 10.





den Dekker HT, Sonnenschein-van der Voort AMM, de Jongste JC, Anessi-Maesano I, Arshad SH, Barros H, Beardsmore CS, Bisgaard H, Phar SC, Craig L, Devereux G, van der Ent CK, Esplugues A, Fantini MP, Flexeder C, Frey U, Forastiere F, Gehring U, Gori D, van der Gugten AC, Henderson AJ, Heude B, Ibarluzea J, Inskip HM, Keil T, Kogevinas M, Kreiner-Møller E, Kuehni CE, Lau S, Mélen E, Mommers M, Morales E, Penders J, Pike KC, Porta D, Reiss IK, Roberts G, Schmidt A, Schultz ES, Schulz H, Sunyer J, Torrent M, Vassilaki M, Wijga AH, Zabaleta C, Jaddoe VWV, Duijts L.

Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children.

J Allergy Clin Immunol. 2016 Apr;137(4):1026-1035. doi: 10.1016/j.jaci.2015.08.050. Epub 2015 Nov 11.


Marshall L, Beardsmore CS, Pescatore AM, Kuehni CE, Gaillard EA.

Airway eosinophils in older teenages with outcrown preschool wheeze: a pilot study

Eur Respir J. 2015 Nov;46(5):1486-9. doi: 10.1183/13993003.00174-2015. Epub 2015 Oct 9. No abstract available.

Dogaru CMNarayanan M, Spycher BD, Pescatore AMOwers-Bradley J, Beardsmore CS, Silverman M, Kuehni CE.  
Breastfeeding, lung volumes and alveolar size at school-age.
BMJ Open Respir Res. 2015 Jul 6;2(1):e000081. doi: 10.1136/bmjresp-2015-000081. eCollection 2015. (PDF document)

Pescatore AM, Spycher BD, Beardsmore CS, Kuehni CE.
"Attacks" or "Whistling": Impact of questionnaire wording on wheeze prevalence estimates.
PLoS One. 2015 Jun 26;10(6):e0131618. doi: 10.1371/journal.pone.0131618. eCollection 2015. (PDF document)

Kuehni CE, Strippoli MF, Spycher BD, Silverman M, Beardsmore CS.  
Lung function in the children of immigrant and UK-born south-Asian mothers.
Eur Respir J. 2015 Apr;45(4):1163-6. doi: 10.1183/09031936.00152114. Epub 2015 Jan 8. (PDF document)

Pescatore AM, Spycher BD, Jurca M, Gaillard EA, Kuehni CE.  
Environmental and socioeconomic data do not improve the Predicting Asthma Risk in Children (PARC) tool
J Allergy Clin Immunol. 2015 May;135(5):1395-1397.e3. doi: 10.1016/j.jaci.2014.10.053. Epub 2014 Dec 26. (PDF document)


Goutaki M, Pescatore AM, Singh P, Beardsmore CS, Kuehni CE.  
Increased prevalence of pre-school wheeze is not explained by time trends in body mass index
Eur Respir J. 2014 Oct;44(4):1078-82. doi: 10.1183/09031936.00011514. Epub 2014 Jun 25. (PDF document)

Dogaru CM, Nyffenegger D, Pescatore AM, Spycher BD, Kuehni CE.  
Dogaru et al. respond to "Does breastfeeding protect against 'asthma'? "
Am J Epidemiol. 2014 May 15;179(10):1171-2. doi: 10.1093/aje/kwu071. Epub 2014 Apr 11. (PDF document)

Dogaru CM, Nyffenegger D, Pescatore AM, Spycher BD, Kuehni CE.  
Breastfeeding and childhood asthma: systematic review and meta-analysis
Am J Epidemiol. 2014 May 15;179(10):1153-67. doi: 10.1093/aje/kwu072. Epub 2014 Apr 11. (PDF document)

Narayanan M, Owers-Bradley J, Beardsmore CS, Kuehni CE, Silverman M.
Reply: On the use of 3He diffusion magnetic resonance as evidence of neo-alveolarization during childhood and adolescence.
Am J Respir Crit Care Med. 2014 Feb 15;189(4):502-4. doi: 10.1164 /rccm. 201311-2032LE. (PDF document)

Pescatore AM, Dogaru CM, Duembgen L, Silverman M, Gaillard EA, Spycher BD, Kuehni CE.
A simple asthma prediction tool for preschool children with wheeze or cough
J Allergy Clin Immunol. 2014 Jan;133(1):111-8.e1-13. doi: 10.1016 /j.jaci. 2013.06. 002. Epub 2013 Jul 24. (PDF document)

Wain LV, Odenthal-Hesse L, Abujaber R, Sayers I, Beardsmore CS, Gaillard EA, Chappell S, Dogaru CM, McKeever T, Guetta-Baranes T, Kalsheker N, Kuehni CE, Hall IP, Tobin MD, Hollox EJ.
Copy number variation of the beta-defensin genes in europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or astham
PLoS One. 2014 Jan 3;9(1):e84192. doi: 10.1371/journal.pone.0084192. eCollection 2014. (PDF document)


Spycher BD, Silverman M, Pescatore AM, Beardsmore CS, Kuehni CE. 
Comparison of phenotypes of childhood wheeze and cough in 2 independent cohorts.
J Allergy Clin Immunol. 2013 Nov;132(5):1058-67. doi: 10.1016/j.jaci.2013.08.002. (PDF document)

Narayanan M, Beardsmore CS, Owers-Bradley J, Dogaru CM, Mada M, Ball I, Garipov RR, Kuehni CE, Spycher BD, Silverman M.
Catch-up Alveolarization in Ex-Preterm Children: evidence from (3)He magnetic resonance
Am J Respir Crit Care Med. 2013 May 15;187(10):1104-9. doi: 10.1164/rccm.201210-1850OC. (PDF document)

Strippoli MP, Kuehni CE, Dogaru CM, Spycher BD, McNally T, Silverman M, Beardsmore CS.
Etiology of Ethnic Differences in Childhood Spiromentry
Pediatrics. 2013 Jun;131(6):e1842-9. doi: 10.1542/peds.2012-3003. (PDF document)


Dogaru CM, Strippoli MP, Spycher BD, Beardsmore CS, Silverman M, Kuehni CE.
Breastfeeding and Lung Function at School-Age: Does Maternal Asthma Modify the Effect?
Am J Respir Crit Care Med 2012; doi:10.1164/rccm.201108-1490OC. (PDF document)


Narayanan M, Owers-Bradley J, Beardsmore CS, Madam M, Ball I, Garipov R, Panesar K, Kuehni CE, Spycher BD, Williams S, Silverman M.
Alveolarization continues during childhood and adolescence: new evidence from 3He magnetic resonance. 
Am J Respir Crit Care Med 2011; doi:10.1164/rccm.201107-1348OC. (PDF document)

Strippoli MPF, Spycher BD, Pescatore AM, Beardsmore CS, Silverman M, Kuehni CE. 
Viral wheezing is virus-specific - not only host-specific (authors's reply). 
Eur Respir J 2011; doi:10.1183/09031936.0016341. (PDF document)

Tischer CG, Hohmann C, ..., Kuehni CE, Strippoli MPF, ..., Keil T, Heinrich J. 
Meta-analysis of mould and dampness exposure on asthma and allergy in eight European birth cohorts: an ENRIECO initiative. 
Allergy 2011;66:1570-9. (PDF document)

Vrijheid M, Casa M, ..., Kuehni CE, ..., Wright J, Nieuwenhuijsen M. 
European birth cohorts for environmental health research. 
Environ Health Perspect 2011;doi: (PDF document)

Kuehni CE. 
Do migrant studies help to identify causes of asthma (editorial)? 
Clin Exp Allergy 2011;41:1054-8. (PDF document)

Leonardi NA, Spycher BD, Strippoli MPF, Frey U, Silverman M, Kuehni CE. 
Validation of the asthma predicitive index and comparison with simpler clinical prediction rules. 
J Allergy Clin Immunol 2011;127:1466-72. (PDF document)

Strippoli MPF, Spycher BD, Pescatore AM, Beardsmore CS, Silverman M, Kuehni CE. 
Exclusive viral wheeze and allergic wheeze: evidence for discrete phenotypes. 
Eur Respir J 2011;38:472-4. (PDF document


Spycher BD, Silverman M, Kuehni CE. 
Phenotypes of childhood asthma: are they real (review). 
Clin Exp Allergy 2010;40:1130-41. (PDF document)

Staley KG, Kuehni CE, Strippoli MPF, McNally T, Silverman M, Stover C. 
Properdin in childhood and its association with wheezing and atopy. 
Pediatr Allergy Immunol 2010;21:e787-91. (PDF document)

Kuehni CE, Spycher BD, Silverman M. 
A role for genes and environment in the causal relationship between infant RSV infection and childhood asthma (author's reply). 
Am J Respir Crit Care Med 2010;181:195. (PDF document)


Spycher BD, Silverman M, Barben J, Eber E, Guinand S, Levy ML, Pao C, van Aalderen WM, von Schayck OCP, Kuehni CE. 
A disease model for wheezing disorders in preschool children based on clinicians' perceptions. 
Plos One 2009;4:e8533. (PDF document

Kuehni CE, Spycher BD, Silverman M. 
Causal link between RSV infection and asthma - no clear answer to an old question (editorial). 
Am J Respir Crit Care Med 2009;179:1079-80. (PDF document)

Spycher BD, Minder CE, Kuehni CE. 
Multivariate modelling of responses to conditional items: new possibilities for latent class analysis. 
Stat Med 2009;28:1972-39. (PDF document)

Spycher BD, Silverman M, Zwahlen M, Brooke AM, Kuehni CE . 
Routine vaccination against pertussis and the risk of childhood asthma: a population-based cohort study. 
Pediatrics 2009;123:944-50. (PDF document)


Spycher BD, Silverman M, Brooke AM, Zwahlen M, Kuehni CE. 
Distinguishing phenotypes of childhod wheeze and cough: a novel approach with prognosis relevance. 
Eur Respir J 2008;31:974-81. (PDF document)

Kuehni CE, Strippoli MPF, Chauliac ES, Silverman M. 
Snoring in preschool children: prevalence, severity and risk factors. 
Eur Respir J 2008;31:326-33. (PDF document)

Spycher BD, Silverman M, Kuehni CE. 
Timing of routine vaccinations and the risk of childhood asthma. 
J Allergy Clin Immunol 2008;122:656. (PDF document)


Silverman M, Kuehni CE. 
Early lung development and COPD (comment). 
Lancet 2007;370:717-9. (PDF document)

Kuehni CE, Strippoli MPF, Low N, Brooke AM, Silverman M. 
Wheeze and asthma prevalence and related health service use in white and south Asian preschool children in the UK. 
Clin Exp Allergy 2007;37:1738-46. (PDF document)

Strippoli MPF, Silverman M, Michel G, Kuehni CE. 
A parent-completed respiratory questionnaire for one-year olfs: repeatability. 
Arch Dis Child 2007;92:861-5. (PDF document)

Kuehni CE, Brooke AM, Strippoli MPF, Spycher BD, Davis A, Silverman M. 
Cohort profile: The Leicester respiratory cohorts. 
Int J Epidemiol 2007;36:977-85. (PDF document)

Kuehni CE, Michel G, Strippoli MPF, Brooke AM, Grigg J, Silverman M. 
Parental understanding of "wheeze" and its impact on asthma prevalence estimates (author's reply). 
Eur Respir J 2007;29:1069-70.

Kuehni CE, Strippoli MPF, Low N, Silverman M. 
Asthma in young south Asian women in the UK: the importance of early life. 
Clin Exp Allergy 2007;37:47-53. (PDF document)

Staley KG, Stover C, Strippoli MPF, Spycher BD, Silverman M, Kuehni CE. 
Mannan-binding lectin in young children with asthma differs by level of severity. 
J Allergy Clin Immunol 2007;119:503-5. (PDF document)


Michel G, Silverman M, Strippoli MPF, Brooke AM, Grigg J, Kuehni CE. 
Parental understanding of "wheeze" and its impact on asthma prevalence estimates. 
Eur Respir J 2006;28:1124-30. (PDF document)

Kuehni CE, Strippoli MPF, Silverman M. 
Food intolerance and wheezing in young south Asian and white children: prevalence and clinical significance. 
J Allery Clin Immunol 118:528-30. (PDF document)

Chauliac E, Silverman M, Zwahlen M, Strippoli MPF, Brooke AM, Kuehni CE. 
The therapy of preschool wheeze: appropriate and fair? 
Pediatr Pulmonol 2006;41:829-38. (PDF document)

Kuehni CE, Strippoli MPF, Zwahlen M, Silverman M. 
Association between exposure to road traffic and respiratory symptoms in children: evidence of bias. 
Int J Epidemiol 2006;35:779-86. (PDF document)

Pierse N, Rushton L, Harris RS, Kuehni CE, Silverman M, Grigg J. 
Locally-generated particulate pollution and respiratory symptoms in young children.
Thorax 2006;61:216-20. (PDF document)


Kuehni CE. 
Phenotype specific treatment of obstructive airways disease in infancy and childhood: new recommendations of the Swiss Paediatric Pulmonology Group.
Swiss Med Wkly 2005;135:95-100. (PDF document)


Stevens CA, Turner D, Kuehni CE, Couriel JM, Silverman M. 
The economic impact of preschool asthma and wheeze.
Eur Respir J 2003;21:1000-6. (PDF document)


Young B, Fitch GE, Dixon-Woods M, Lambert PC, Brooke AM. 
Parent's accounts of wheeze and asthma related symptoms: a qualitative study.
Arch Dis Child 2002;87:131-4. (PDF document)

Dixon-Woods M,  Anwar Z, Young B, Fitch GE, Brooke AM. 
Lay evaluation of services for childhood asthma.
Health Soc Care Community 2002;10:503-11. (PDF document)


Kuehni CE, Davis A, Brooke AM, Silverman M. 
Are all wheezing disorders in very young (preschool) children increasing in prevalence?
Lancet 2001;357:1821-5. (PDF document)

Kuehni CE, Brooke AM, Davis A, Silverman M. 
Vaccinations as risk factors for wheezing disorders.
Lancet 2001;358:1186. (PDF document)


Kuehni CE, Brooke AM, Silverman M. 
Prevalence of wheezing during childhood: retrospective and prospective assessment.
Eur Respir J 2000;16:81-5. (PDF document)


Brooke AM, Lambert PC, Burton PR, Clarke C, Luyt DK, Simpson H. 
Recurrent cough: natural history and significance in infancy and early childhood.
Pediatr Pulmonol 1998;26:256-61. (PDF document)


Brooke AM, Lambert PC, Burton PR, Clarke C, Luyt DK, Simpson H. 
Night cough in a population-based sample of children: charateristics, relation to symptoms and associations with measures of asthma severity.
Eur Respir J 1996;9:65-71. (PDF document)


Luyt DK, Brooke AM, Lambert PC, Burton PR, Simpson H. 
Wheeze in preschool children: who is followed-up, who is treated and who is hospitalised?
Eur Respir J 1995;8:1736-41. (PDF document)

Brooke AM, Lambert PC, Burton PR, Clarke C, Luyt DK, Simpson H. 
The natural history of respiratory symptoms in preschool children.
Am J Respir Crit Care Med 1995;152:1872-8. (PDF document)


Riordan MF, Beardsmore CS, Brooke AM, Simpson H. 
Relationship between respiratory symptoms and cough receptor sensitivity.
Arch Dis Child 1994;70:299-304. (PDF document)

Luyt DK, Burton PR, Brooke AM, Simpson H. 
Wheeze in preschool children and its relation with doctor diagnosed asthma.
Arch Dis Child 1994;71:24-30. (PDF document)


Luyt DK, Burton PR, Simpson H. 
Epidemiological study of wheeze, doctor diagnosed ashtma, and cough in preschool children in Leicestershire.
BMJ 1993;306:1386-90. (PDF document)

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